Endocrine disrupting properties of perfluorooctanoic acid

The Endocrine Disrupting Effect of Perfluorooctanoic Acid (PFOA) on Human Estrogen, Androgen and Thyroid Receptors

The health effects of perfluorooctanoic acid (PFOA) on humans remain controversial because of contradictory experimental and epidemiological studies. In this study, we used three-dimensional quantitative structure-activity relationship (3D-QSAR) method by applying Surflex-dock to study the binding modes between PFOA and human estrogen receptor (hERα), human androgen receptor (hAR) and human thy...

Endocrine disrupting chemicals

The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...

Endocrine Disrupting Pesticides

Cryptorchidism and endocrine disrupting chemicals

Prospective clinical studies have suggested that the rate of congenital cryptorchidism has increased since the 1950s. It has been hypothesized that this may be related to environmental factors. Testicular descent occurs in two phases controlled by Leydig cell-derived hormones insulin-like peptide 3 (INSL3) and testosterone. Disorders in fetal androgen production/action or suppression of Insl3 a...

Perfluorooctanoic Acid for Shotgun Proteomics

Here, we describe the novel use of a volatile surfactant, perfluorooctanoic acid (PFOA), for shotgun proteomics. PFOA was found to solubilize membrane proteins as effectively as sodium dodecyl sulfate (SDS). PFOA concentrations up to 0.5% (w/v) did not significantly inhibit trypsin activity. The unique features of PFOA allowed us to develop a single-tube shotgun proteomics method that used all ...